architectures
There are various set-ups for bacterial tet-regulation. Variables among the involved genetic components include the absolute and relative location of tetR and the target gene (i.e. chromosomal or episomal, cis or trans), the number and position of tetO sites within the target gene promoter (see figure) or the kind of tetR expression ((auto)regulated or constitutive). The tables below schematize architectures described in selected publications. The upper table lists set-ups, in which tetR and the target gene are located adjacent on the same DNA molecule, the table below contains examples of spatially separated tetR and target gene architectures.
