Research Group Jürgens


Selected Publications


Karnahl M, Park M, Krause C, Hiller U, Mayer U, Stierhof Y-D, Jürgens G (2018). Functional diversification of Arabidopsis SEC1-related SM proteins in cytokinetic and secretory membrane fusion. PNAS 115 (doi/10.1073/pnas.1722611115)

Park M, Krause C, Karnahl M, Reichardt I, El Kasmi F, Mayer U, Stierhof Y-D, Hiller U, Strompen G, Bayer M, Kientz M, Sato MH, Nishimura MT, Dangl JL, Sanderfoot AA, Jürgens G (2018). Concerted action of evolutionarily ancient and novel SNARE complexes in flowering-plant cytokinesis. Dev Cell 44, 500-511


Karnahl M, Park M, Mayer U, Hiller U, Jürgens G (2017). ER assembly of SNARE complexes mediating formation of partitioning membrane in Arabidopsis cytokinesis. eLife 6: e25327


Müller S, Jürgens G (2016). Plant cytokinesis – no ring, no constriction but centrifugal construction of the partitioning membrane. Sem Cell Dev Biol 53: 10-18


Jürgens G, Park M, Richter S, Touihri S, Krause C, El Kasmi F, Mayer U (2015). Plant cytokinesis – a tale of membrane traffic and fusion. Biochem. Soc. Trans. 43: 73-78


Singh MK, Krüger F, Beckmann H, Brumm S, Vermeer JEM, Munnik T, Mayer U, Stierhof YD, Grefen C, Schumacher K, Jürgens G (2014). Protein delivery to vacuole requires SAND protein-dependent Rab GTPase conversion for MVB-vacuole fusion. Curr. Biol. 24: 1383-1389

Richter S, Kientz M, Brumm S, Nielsen ME, Park M, Gavidia R, Krause C, Voss U, Beckmann H, Mayer U, Stierhof YD, Jürgens G (2014). Delivery of endocytosed proteins to the cell-division plane requires change of pathway from recycling to secretion. eLife 3: e02131


Kim S, Xu ZY, Song KY, Kim DH, Kang H, Reichardt I, Sohn EJ, Friml J, Juergens G, Hwang I (2013). Adaptor protein complex 2-mediated endocytosis is crucial for male reproductive organ development in Arabidopsis. Plant Cell 25: 2970-2985

Park M, Song KY, Reichardt I, Kim H, Mayer U, Stierhof YD, Hwang I, Jürgens G (2013). Arabidopsis AP1M adaptin subunit of adaptor protein complex 1 mediates late secretory and vacuolar traffic and is required for growth. PNAS 110: 10318–10323

El Kasmi F, Krause C, Hiller U, Stierhof YD, Mayer U, Conner L, Kong L, Reichardt I, Sanderfoot AA, Jürgens G (2013). SNARE complexes of different composition jointly mediate membrane fusion during cytokinesis in Arabidopsis. Mol. Biol. Cell 24: 1593-1601


Park M, Touihri S, Müller I, Mayer U, Jürgens G (2012). Sec1/Munc18 protein stabilizes fusion-competent syntaxin for membrane fusion in Arabidopsis cytokinesis. Dev. Cell 22:989-1000

Rademacher, E.H., Lokerse, A.S. Schlereth, A., Peris, C.L., Bayer, M., Kientz, M., Rios, A.F., Borst, J.-W., Lukowitz, W., Jürgens, G., Weijers, D. (2012). Different auxin response machineries control distinct cell fates in the early plant embryo. Dev. Cell 22:211-222.

Richter, S., Müller, L., Takada, N., Kost, B., Vieten, A., Geldner, N., Koncz, C., Stierhof, Y.-D., Mayer, U., Jürgens, G. (2012). Polarized cell growth in Arabidopsis requires endosomal recycling mediated by GBF1-related ARF exchange factors. Nature Cell Biol. 14:80-86.


Touihri, S., Knöll, C., Stierhof, Y.-D., Müller, I., Mayer, U., Jürgens, G. (2011). Functional anatomy of Arabidopsis cytokinesis-specific syntaxin KNOLLE. Plant J. 68:755-764.

Reichardt, I., Slane, D., El Kasmi, F., Knöll, C., Fuchs, R., Mayer, U., Lipka, V., Jürgens, G. (2011). Mechanisms of functional specificity among plasma-membrane syntaxins in Arabidopsis. Traffic 12:1269-1280.

El Kasmi, F., Pacher, T., Strompen, G., Stierhof, Y.-D., Müller, L.M., Koncz, C., Mayer, U., Jürgens, G. (2011). Arabidopsis SNARE protein SEC22 is essential for gametophyte development and maintenance of Golgi-stack integrity. Plant J. 66:268-279.

Wolters, H., Anders, N., Geldner, N., Gavidia, R., Jürgens, G. (2011). Coordination of apical and basal embryo development revealed by tissue-specific GNOM functions. Development 138:117-126.


De Smet, I., Lau, S., Voss, U., Vanneste, S., Benjamins, R., Rademacher, E.H., Schlereth, A., De Rybel, B., Vassileva, V., Grunewald, W., Naudts, M., Levesque, M.P., Ehrismann, J.S., Inzé, D., Luschnig, C., Benfey, P.N., Weijers, D., Van Montagu, M.C., Bennett, M.J., Jürgens, G., Beeckman, T. (2010). Bimodular auxin response controls organogenesis in Arabidopsis. PNAS 107(6):2705-10.

Jürgens, G. (2010). Mechanisms of cell behaviour in eukaryotes. Eur J Cell Biol. 89(2-3):125.

Lau, S., Ehrismann, J.S., Schlereth, A., Takada, S., Mayer, U., Jürgens, G. (2010). Cell-cell communication in Arabidopsis early embryogenesis. Eur J Cell Biol. 89(2-3):225-230.

Richter, S., Anders, N., Wolters, H., Beckmann, H., Thomann, A., Heinrich, R., Schrader, J., Singh, M.K., Geldner, N., Mayer, U., Jürgens, G. (2010).Role of the GNOM gene in Arabidopsis apical-basal patterning--From mutant phenotype to cellular mechanism of protein action. Eur J Cell Biol. 89(2-3):138-44.

Schlereth, A., Möller, B., Liu, W., Kientz, M., Flipse, J., Rademacher, E.H., Schmid, M., Jürgens, G., Weijers, D. (2010). MONOPTEROS controls embryonic root initiation by regulating a mobile transcription factor. Nature 464:913-6.


Boutté, Y., Frescatada-Rosa, M., Men, S., Chow, C.M., Ebine, K., Gustavsson, A., Johansson, L., Ueda, T., Moore, I., Jürgens, G., Grebe, M. (2009). Endocytosis restricts Arabidopsis KNOLLE syntaxin to the cell division plane during late cytokinesis. EMBO J. 29(3):546-58.

De Smet, I., Voss, U., Jürgens, G., Beeckman, T. (2009). Receptor-like kinases shape the plant. Nature Cell Biology 11(10):1166-73.

Krupnova, T., Sasabe, M., Ghebreghiorghis, L., Gruber, C.W., Hamada, T., Dehmel, V., Strompen, G., Stierhof, Y.D., Lukowitz, W., Kemmerling, B., Machida, Y., Hashimoto, T., Mayer, U., Jürgens, G. (2009). Microtubule-associated kinase-like protein RUNKEL needed [corrected] for cell plate expansion in Arabidopsis cytokinesis. Curr Biol. 19(6):518-23.

Lau, S., Shao, N., Bock, R., Jürgens, G., De Smet, I. (2009). Auxin signaling in algal lineages: fact or myth? Trends Plant Sci. 14(4):182-8.

Lee, S., Lee, D.W., Lee, Y., Mayer, U., Stierhof, Y.D., Lee, S., Jürgens, G., Hwang, I. (2009). Heat shock protein cognate 70-4 and an E3 ubiquitin ligase, CHIP, mediate plastid-destined precursor degradation through the ubiquitin-26S proteasome system in Arabidopsis. Plant Cell 21(12):3984-4001.

Richter, S., Voss, U., Jürgens, G. (2009). Post-Golgi traffic in plants. Traffic 10(7):819-28.

Wolters, H., Jürgens, G. (2009). Survival of the flexible: hormonal growth control and adaptation in plant development. Nat. Rev. Genet. 10(5):305-17.


Anders, N., Nielsen, M., Keicher, J., Stierhof, Y.D., Furutani, M., Tasaka, M., Skriver, K., Jürgens, G. (2008). Membrane association of the Arabidopsis ARF exchange factor GNOM involves interaction of conserved domains. Plant Cell 20(1):142-51.

De Smet, I., Vassileva, V., De Rybel, B., Levesque, M.P., Grunewald, W., Van Damme, D., Van Noorden, G., Naudts, M., Van Isterdael, G., De Clercq, R., Wang, J.Y., Meuli, N., Vanneste, S., Friml, J., Hilson, P., Jürgens, G., Ingram, G.C., Inzé, D., Benfey, P.N., Beeckman, T. (2008). Receptor-like kinase ACR4 restricts formative cell divisions in the Arabidopsis root. Science 322(5901):594-7.

Dohmann, E.M., Levesque, M.P., De Veylder, L., Reichardt, I., Jürgens, G., Schmid, M., Schwechheimer, C. (2008). The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability. Development 135(11):2013-22.

Kwon, C., Neu, C., Pajonk, S., Yun, H.S., Lipka, U., Humphry, M., Bau, S., Straus, M., Kwaaitaal, M., Rampelt, H., El Kasmi, F., Jürgens, G., Parker, J., Panstruga, R., Lipka, V., Schulze-Lefert, P. (2008). Co-option of a default secretory pathway for plant immune responses. Nature 451(7180):835-40.

Lau, S., Jürgens, G., De Smet, I. (2008). The evolving complexity of the auxin pathway. Plant Cell 20(7):1738-46.

Stepanova, A.N., Robertson-Hoyt, J., Yun, J., Benavente, L.M., Xie, D.Y., Dolezal, K., Schlereth, A., Jürgens, G., Alonso, J.M. (2008). TAA1-mediated auxin biosynthesis is essential for hormone crosstalk and plant development. Cell 133(1):177-91.

Thiele, K., Wanner, G., Kindzierski, V., Jürgens, G., Mayer, U., Pachl, F., Assaad, F.F. (2008). The timely deposition of callose is essential for cytokinesis in Arabidopsis. Plant Journal 58:13-26.

Tucker, M.R., Hinze, A., Tucker, E.J., Takada, S., Jürgens, G., Laux, T. (2008). Vascular signalling mediated by ZWILLE potentiates WUSCHEL function during shoot meristem stem cell development in the Arabidopsis embryo. Development 135(17):2839-43.


De Smet I, Jürgens G. (2007). Patterning the axis in plants--auxin in control. Curr Opin Genet Dev 17:337-343.

Haga, N., Kato, K., Murase, M., Araki, S., Kubo, M., Demura, T., Suzuki, K., Muller, I., Voss, U., Jürgens,G., Ito, M. (2007). R1R2R3-Myb proteins positively regulate cytokinesis through activation of KNOLLE transcription in Arabidopsis thaliana. Development 134, 1101-1110.

Jürgens, G., Geldner, N. (2007). The high road and the low road: trafficking choices in plants. Cell 130(6):977-9.

Reichardt, I., Stierhof, Y.D., Mayer, U., Richter, S., Schwarz, H., Schumacher, K., Jürgens, G. (2007) Plant cytokinesis requires de novo secretory trafficking but not endocytosis. Curr Biol. 17(23):2047-53.

Richter, S., Geldner, N., Schrader, J., Wolters, H., Stierhof, Y.D., Rios, G., Koncz, C., Robinson, D.G., Jürgens, G. (2007). Functional diversification of closely related ARF-GEFs in protein secretion and recycling. Nature 448, 488-492.

Takada, S., Jürgens, G. (2007). Transcriptional regulation of epidermal cell fate in the Arabidopsis embryo. Development 134, 1141-1150.


Geldner, N., Jürgens, G. (2006). Endocytosis in signalling and development. Curr Opin Plant Biol. 9:589-594.

Weijers, D., Schlereth, A., Ehrismann, J.S., Schwank, G., Kientz, M., Jurgens, G. (2006). Auxin triggers transient local signaling for cell specification in Arabidopsis embryogenesis. Dev. Cell 10, 265-270.


Jürgens, G. (2005). Cytokinesis in higher plants. Annu Rev Plant Biol. 56:281-299.

Jürgens, G. (2005) Plant cytokinesis: fission by fusion. Trends Cell Biol 15, 277-283.

Strompen, G., Dettmer, J., Stierhof, Y.D., Schumacher, K., Jürgens, G., Mayer, U. (2005). Arabidopsis vacuolar H-ATPase subunit E isoform 1 is required for Golgi organization and vacuole function in embryogenesis. Plant J. 41:125-132.

Weigel D, Jürgens G. (2005) Genetics: hotheaded healer. Nature 434(7032):443.

Weijers, D., Benkova, E., Jäger, K.E., Schlereth, A., Hamann, T., Kientz, M., Wilmoth, J.C., Reed, J.W., Jürgens, G. (2005). Developmental specificity of auxin response by pairs of ARF and Aux/IAA transcriptional regulators. EMBP J. 24(10):1874-85.

Weijers, D., Jürgens, G. (2005) Auxin and embryo axis formation: the ends in sight? Curr Opin Plant Biol 8, 32-37.


Geldner, N., Richter, S., Vieten, A., Marquardt, S., Torres-Ruiz, R.A., Mayer, U., Jürgens, G. (2004). Partial loss-of-function alleles reveal a role for GNOM in auxin transport-related, post-embryonic development of Arabidopsis. Development 131(2):389-400.

Schrick, K., Fujioka, S., Takatsuto, S., Stierhof, Y.D., Stransky, H., Yoshida, S., Jürgens, G. (2004). A link between sterol biosynthesis, the cell wall, and cellulose in Arabidopsis. Plant J. 38(2):227-43.


Friml, J., Vieten, A., Sauer, M., Weijers, D., Schwarz, H., Hamann, T., Offringa, R., Jürgens, G. (2003) Efflux dependent auxin gradients establish the apical-basal axis of Arabidopsis. Nature 426, 147-153.

Geldner, N., Anders, N., Wolters, H., Keicher, J., Kornberger, W., Muller, P., Delbarre, A., Ueda, T., Nakano, A., Jürgens, G. (2003). The Arabidopsis GNOM ARF-GEF mediates endosomal recycling, auxin transport, and auxin-dependent plant growth. Cell 112(2), 219-30.

Müller, I., Wagner, W., Völker, A., Schellmann, S., Nacry, P., Küttner, F., Schwarz-Sommer, Z., Mayer, U., Jürgens, G. (2003). Syntaxin specificity of cytokinesis in Arabidopsis. Nature Cell Biology 5, 531 - 534.


Hamann, T., Benkova, E., Baurle, I., Kientz, M., Jurgens, G. (2002) The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning. Genes Dev.16(13):1610-5.

Steinborn, K., Maulbetsch, C., Priester, B., Trautmann, S., Pacher, T., Geiges, B., Küttner, F., Lepiniec, L., Stierhof, Y.-D., Schwarz, H., Jürgens, G., Mayer, U. (2002). The Arabidopsis PILZ group genes encode tubulin-folding cofactor orthologs required for cell division but not cell growth. Genes & Dev. 16, 959-971.

Strompen, G., El Kasmi, F., Richter, S., Lukowitz, W., Assaad, F., Schwarz, H., Jürgens, G., Mayer, U. (2002). The Arabidopsis HINKEL gene encodes a kinesin-related protein involved in cytokinesis and is expressed in a cell cycle-dependent manner. Curr. Biol. 12, 153-158.


Assaad, F.F., Huet, Y., Mayer, U., Jürgens, G. (2001). The cytokinesis gene KEULE encodes a Sec1 protein which binds the syntaxin KNOLLE. J. Cell Biol. 152, 531-544.

Geldner, N., Friml, J., Stierhof, Y.-D., Jürgens, G., Palme, K. (2001). Auxin-transport inhibitors block PIN1 cycling and vesicle trafficking. Nature 413, 425-428.

Heese, M., Gansel, X., Sticher, L., Wick, P., Grebe, M., Granier, F., Jürgens, G. (2001). Functional characterization of the KNOLLE-interacting t-SNARE AtSNAP33 and its role in plant cytokinesis. J. Cell Biol. 155, 239-250.

Jürgens, G. (2001). Apical-basal pattern formation in Arabidopsis embryogenesis. EMBO J. 20, 3609-3616.

Völker, A., Stierhof, Y.-D., Jürgens, G. (2001). Cell cycle-independent expression of the Arabidopsis cytokinesis-specific syntaxin KNOLLE results in mistargeting to the plasma membrane and is not sufficient for cytokinesis. J. Cell Sci. 114, 3001-3012.

Weijers, D., Geldner, N., Offringa, R., Jürgens, G. (2001). Early paternal gene activity in Arabidopsis. Nature 414, 709-710.

- 2000

Grebe, M., Gadea, J., Steinmann, T., Kientz, M., Rahfeld, J.U., Salchert, K., Koncz, C., Jürgens, G. (2000). A conserved domain of the Arabidopsis GNOM protein mediates subunit interaction and cyclophilin 5 binding. Plant Cell 12, 343-356.

Nacry, P., Mayer, U., Jürgens, G. (2000). Genetic dissection of cytokinesis. In: The Plant Cell Cycle (ed. D. Inzé). Plant Mol. Biol. 43, 719-733.

Waizenegger, I., Lukowitz, W., Assaad, F., Schwarz, H., Jürgens, G., Mayer, U. (2000). The Arabidopsis KNOLLE and KEULE genes interact to promote vesicle fusion during cytokinesis. Curr. Biol. 10, 1371-1374.

Hamann, T., Mayer, U., Jürgens, G. (1999). The auxin-insensitive bodenlos mutation affects primary root formation and apical-basal patterning in the Arabidopsis embryo. Development 126, 1387-1395.

Steinmann, T., Geldner, N., Grebe, M., Mangold, S., Jackson, C.L., Paris, S., Gälweiler, L., Palme, K., Jürgens, G. (1999). Coordinated polar localization of auxin efflux carrier PIN1 by GNOM ARF GEF. Science 286, 316-318.

Lauber, M.H., Waizenegger, I., Steinmann, T., Schwarz, H., Mayer, U., Hwang, I., Lukowitz, W., Jürgens, G. (1997). The Arabidopsis KNOLLE protein is a cytokinesis-specific syntaxin. J. Cell Biol. 139, 1485-1493.

Busch, M., Mayer, U., Jürgens, G. (1996). Molecular analysis of the Arabidopsis pattern-formation gene GNOM: gene structure and intragenic complementation. Molec. Gen. Genet. 250, 681-691.

Lukowitz, W., Mayer, U., Jürgens, G. (1996). Cytokinesis in the Arabidopsis embryo involves the syntaxin-related KNOLLE gene product. Cell 84, 61-71.

Jürgens, G., Mayer, U. (1994). Arabidopsis. In: EMBRYOS. Colour Atlas of Development. J.B.L. Bard (ed.), pp. 7-21. Wolfe Publishing, London.

Mayer, U., Büttner, G., Jürgens, G. (1993). Apical-basal pattern formation in the Arabidopsis embryo: studies on the role of the gnom gene. Development 117, 149-162.

Mayer, U., Torres Ruiz, R.A., Berleth, T., Miséra, S., Jürgens, G. (1991). Mutations affecting body organization in the Arabidopsis embryo. Nature 353, 402-407.