Research fields
Combinatorial Organic Chemistry and Instrumental Methods
for Lead Structure Search and Lead Optimization
- Design of high throughput synthesis of combinatorial organic
compound collections with structurally diverse scaffolds.
- Method developments for automated parallel production on solid
phase and ploymer assisted solution phase synthesis.
- Production methods for large peptide and peptidomimetics libraries.
- Fast high resolving instrumental analysis (micro/nano-HPLC-FTICR-MS,
single bead analysis, IR microscopy, fluorescence correlation spectroscopy).
Natural Products: Structure Elucidation, Synthesis and
Biosynthesis
- Isolation and structure elucidation of microbial metabolites,
antibiotics.
- Potential-dependent channel formers (peptaibols).
- Microbial polypeptides with posttranslation backbone modifications:
structure activity relationships, lantibiotics, microcins, vancomycins,
characterization of new enzymes.
- Elucidation of new iron chelators.
- Structure-activity relationships of hormones and protease inhibitors
based on peptidomimetics.
Immunochemistry and Biochemistry of T Cell Recognition
- Elucidation of exact sequence motifs of MHC I and II ligands
using combinatorial peptide libraries and binding assays: elucidation
of the allele specific immunological codes.
- Development of superagonists and peptidomimetic antagonists
of T-cells involved in autoimmune deseases and cancer.
- Synthetic vaccines based on lipopeptides with built-in adjuvants, B-,
T-helper and T-killer cell epitopos.
- Complete epitope mapping of viral proteins and pathogenes.
- Structure-activity realtionships of ligands for toll-like receptors.
Biosensors and Chemosensors
- Development of sensors based on combinatorial peptide arrays.
- Microstructured peptide funtionalized chip surfaces.
- Matrix supported bilayers and biofunctionalized sensor substrates.
- Synthetic potential-dependent transmembrane ion carriers and
natural transporters.
- Chiral recognition by synthetic cyclopeptide arrays as receptors.
- Affinity matrices
Protein/DNA interaction and Transfer Agents for DNA/RNA
- Synthetic gen transfer agents.
- RNA vaccines.
- Peptide/DNA interaction.
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