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Filaria infections
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Among the parasitic diseases that result from an infection with filarial nematodes,
onchocerciasis
and
lymphatic filariasis
are the two most prevalent diseases,
with ~17 million and ~120 million people being infected, respectively.
Both diseases can substantially impair the individual
(pathology, increased mortality) and the population (socioeconomic development)
and are subject to major intervention programs by the World Health Organization
(WHO).
The Onchocerciasis Control Programme
(OCP),
initiated in 1974
in seven West African countries and performed over an extended area until the end of 2002,
was based on vector control by aerial application of larvicides.
Its successor program, the African Programme for Onchocerciasis Control
(APOC),
relies mainly on mass drug administration of the microfilaricide ivermectin.
The Global Programme to Eliminate Lymphatic Filariasis
(GPELF)
was launched in 1998
and is based on mass drug administration of various microfilaricides.
With our work, with the methods of modeling and simulation,
we try to support the control of these diseases,
to improve our understanding of what the parasite makes persisting,
and thus, to understand how we can optimize the control of these diseases.
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