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Nodulectomy data
The data originate from two nodulectomy campaigns conducted in the 1970s
in the West African countries of Burkina Faso and Liberia. In a nodulectomy,
the nodules, which harbour single or aggregated female Onchocerca volvulus,
are surgically excised from the skin of patients.
The complete parasites are isolated after enzymatically digesting
the connective tissue (Schulz-Key et al., 1977)
which forms the solid capsule of the nodule.
Descriptive findings of investigations into this data set
can be found in earlier publications (see references below).
One of the intentions of these nodulectomy campaigns was
to interrupt the transmission of the disease by the concerted removal
of parasites from the human population.
This hope, however, could not be fulfilled because it turned out
that the regulatory mechanisms by which the parasite achieves a
stable anchoring in the host population is much more effective
than assumed at that times.
The accurate data collection has led to a unique data set
which allows investigating interactions in the host-parasite relationship.
Besides host-specific information, the data set lists
the number of parasites for every excised nodule and
their reproductive stage and status of viability.
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Homestead near Kourougbele, Burkina Faso (Photo: D.W. Büttner)
Mauwa near St. Paul river, Liberia
(Photo: D.W. Büttner)
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Related pages:
Nodules,
Diagnosis by palpation of nodules.
Literature:
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Albiez, E. J., 1983. Studies on nodules and adult Onchocerca volvulus during a nodulectomy trial in hyperendemic villages in Liberia and Upper Volta. I. Palpable and impalpable onchocercomata. Tropenmed. Parasitol. 34, 54-60.
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Albiez, E. J., 1985. Effects of a single complete nodulectomy on nodule burden and microfilarial density two years later. Trop. Med. Parasitol. 36, 17-20.
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Albiez, E. J., Büttner, D. W., Schulz-Key, H., 1984. Studies on nodules and adult Onchocerca volvulus during a nodulectomy trial in hyperendemic villages in Liberia and Upper Volta. II. Comparison of the macrofilaria population in adult nodule carriers. Tropenmed. Parasitol. 35, 163-166.
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Albiez, E. J., Schulz-Key, H., Brinkmann, U. K., 1978. Comparative studies on the quantitative assessment of microfilarial densities in onchocerciasis. Trans. R. Soc. Trop. Med. Hyg. 72, 417-9.
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Schulz-Key, H., 1990. Observations on the reproductive biology of Onchocerca volvulus. Acta Leiden. 59, 27-44.
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Schulz-Key, H., Albiez, E. J., 1977. Worm burden of Onchocerca volvulus in a hyperendemic village of the rain-forest in West Africa. Tropenmed. Parasitol. 28, 431-438.
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Schulz-Key, H., Albiez, E. J., Büttner, D. W., 1977. Isolation of living adult Onchocerca volvulus from nodules. Tropenmed. Parasitol. 28, 428-430.
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Responsible for this page:
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Dr. H.-P. Duerr
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Webmaster:
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Prof. Dr. M. Eichner
(last change of this page on
13 July 2009)
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Further project partners:
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Prof. H. Schulz-Key, Institute for Tropical Medicine, University of Tübingen, Germany
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Prof. D. W. Büttner, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany
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Disclaimer:
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Eberhard-Karls-University Tübingen,
Tübingen University Hospital,
the Department for Medical Biometry (IMB),
and the authors of this page disclaim all liability for the content of any page referenced by hyper-link from this page
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