An evaluation of historical data revealed that most people who were vaccinated once during infancy lost their protection against infection within one or two decades.
Nevertheless, a high percentage of patients were protected against severe smallpox disease even years after vaccination, and many patients retained a life-long protection against fatal disease.
Eberhard-Karls-University Tübingen,
Tübingen University Hospital,
the Department for Medical Biometry (IMB),
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