Prediction Algorithm for Proteasomal Cleavages

 PAProC's location within the MHC class I antigen processing pathway.
User information on PAProC functions
Background information on proteasomes and PAProC
Name of the amino acid sequence:
Type in your amino acid sequence (in 1-letter-code)

Which proteasome species should be used ?

Human proteasome Yeast proteasome
wild type I wild type
wild type II beta5/Pre2- single mutant
wild type III beta1/Pre3- single mutant
beta2/Pup1- single mutant
beta2/Pup1- beta1/Pre3- double mutant

Please choose the output style :
short form long form



This program was developed at the University of Tübingen, Germany, at the Department of Biomathematics and at the Department of Immunology .
We would be grateful for any feedback ! E-mail: alexander.nussbaum@uni-tuebingen.de or christina.kuttler@uni-tuebingen.de

Last update: 10.10.2000 - Version 1.0
You are visitor number counter since August 2000.

Please cite the following article, if you want to publish the results of the program:
C. Kuttler, A.K. Nussbaum, T.P. Dick, H.-G. Rammensee, H. Schild, K.P. Hadeler, An algorithm for the prediction of proteasomal cleavages, J. Mol. Biol. 298 (2000), 417-429
The use of PAProC is restricted to non-commercial purposes.
Inner surface of the yeast 20S proteasome; yellow: inhibitors bound to the three active sites [Groll et al. (1997), Nature].