Welcome to the Molecular Recognition HomePage!

The worker:

Martin Jäger

The work:

Particular molecules recognize each other, associate and form lock-and-key complexes. They interact through the formation of specific non-covalent attractions.

The influence of intermolecular interactions on molecular dynamic processes are studied by using phenoxyl substituted adenine or benzimidazole derivatives respectively as substrates and the receptor "Rebek's cleft".

The internal motion and the intermolecular equilibria are investigated by means of Nuclear and Electron Magnetic Resonance techniques.

We could show that it is possible:

a) to analyze molecular recognition with EMR methods.

b) to distinguish between specific and non-specific interactions.

c) to observe different internal dynamic processes, p.e. two-jump and two-site mechanisms, according to the type of interactions.

d) to estimate relative conformations of the substrates.

Publications:

1. Martin Jäger and Hartmut B. Stegmann "Molecular Recognition analyzed by EPR, ENDOR and NMR Spectroscopy" Angew. Chem. 108, 1943; Angew. Chem. Int. Ed. Engl. 35, 1815 (1996).

2. Martin Jäger, Paul Schuler, Antal Rockenbauer and Hartmut B. Stegmann "Molecular Recognition II: Discrimination of Specific and Non-Specific Intermolecular Interactions by Means of Magnetic Resonance Spectroscopy" Magn. Res. Chem. accepted