Selected Publications

 

 

last update:January 18, 2008

 

2007

Spreu, J., Kienle, E., Schrage, B., & Steinle, A. CLEC2A: a novel, alternatively spliced and skin-associated member of the NKC-encoded AICL-CD69-LLT1 family. Immunogenetics 59:903-12 (2007) .

 

2006

Welte, S., Kuttruff, S., Waldhauer, I. & Steinle, A. Mutual activation of natural killer cells and monocytes mediated by NKp80-AICL interaction.Nature Immunology 7:1334-1342 (2006) .

Spreu, J., Stehle, T. & Steinle, A. Human cytomegalovirus-encoded UL16 discriminates MIC molecules by their alpha2 domains. Journal of Immunology 177:3143-9 (2006).

Eisele, G., Wischusen, J., Mittelbronn, M., Mexermann, R., Waldhauer, I., Steinle, A., Weller, M. & Friese, M.A. TGF-beta and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells. Brain 129:2416-25 (2006).

Waldhauer, I. & Steinle, A. Proteolytic release of soluble UL16-binding protein 2 from tumor cells. Cancer Research 66:2520-6 (2006).

Salih, H.R., Goehlsdorf, D. & Steinle, A. release of MICB molcules by tumor cells: mechanism and soluble MICB in sera of cancer patients. Human Immunology 67: 188-95 (2006).

Holdenrieder, S., Stieber, P., Peterfi, A., Nagel, D., Steinle, A . & Salih, H.R. Soluble MICA in malignant diseases. International Journal of Cancer 118:684-7 (2006).

 

2005

Wiemann, K., Mittrücker, H.W., Feger, U., Welte, S., Yokoyama, W.M., Spies, T., Rammensee, H.-G. & Steinle, A . Systemic NKG2D downregulation impairs NK and CD8 T cell responses in vivo. Journal of Immunology 175:720-729 (2005).

Wiemann, K. & Steinle, A. Danger-Detector NKG2D: Immunosurveillance of Induced Self and Modulation by Cytokines and Soluble Ligands. Current Medicinal Chemistry – Anti-Inflammatory & Anti-Allergy Agents 4:141-152 (2005).

Rincon-Orozco, B., Kunzmann, V., Wrobel, P., Kabelitz, D.,Steinle, A & Herrmann, T. Activation of Vg9Vd2 T cells by NKG2D. Journal of Immunology 175:2144-2151 (2005).

Armeanu, S., Bitzer, M., Lauer, U.M., Venturelli, S., Pathil, A., Kaiser, S., Jobst, J., Smirnow, I. , Wagner, A., Steinle, A . & Salih, H.R. NK cell-mediated lysis of hepatoma cells via specific induction of NKG2Dligands by the histone deacatylase inhibitor sodium valproate. Cancer Research 65:6321-6329 (2005).

 

2004

Friese, M.A., Wischhusen, J., Wick, W., Weiler, M., Eisele, G., Steinle, A. & Weller, M. RNA interference targeting transforming growth factor-b enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo. Cancer Research 64:7596-7603 (2004).

Wu, D.J., Higgins, L.M., Steinle, A., Cosman, D., Haugk K., & Plymate S.R. Prevalent expression of immunostimulatory MIC molecule is counteracted by shedding in prostate cancer. Journal of Clinical Investigation 114 :560-568 (2004).

 

2003

Salih, H.R., Antropius, H., Gieseke, F., Lutz, S.Z., Kanz, L., Rammensee, H.-G. & Steinle, A. Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia. Blood 102:1389-1396 (2003).

Welte, S., Sinzger, C., Lutz, S.Z., Singh-Jasuja, H., Laib-Sampaio, K., Eknigk, U., Rammensee, H.-G. & Steinle, A. Selective intracellular retention of virally induced NKG2D-ligands by the human cytomegalovirus glycoprotein UL16. European Journal of Immunology 33:194-203 (2003).

Friese, M.A., Platten, M., Lutz, S.Z., Naumann, U., Aulwurm, S., Bischof, F., Bühring, H.-J., Dichgans, J., Rammensee, H.-G., Steinle, A.& Weller, M. NKG2D mediated immunogene therapy of experimental gliomas. Cancer Research 63: 8996-9006 (2003).

 

2002

Salih, H.R., Rammensee, H.-G. & Steinle, A. Cutting Edge: Down-regulation of MICA on human tumors by proteolytic shedding. Journal of Immunology 169: 4098-4102 (2002).

 

2001

Steinle, A., Li, P., Morris, D.L., Groh, V., Lanier, L.L., Strong, R.K. & Spies, T. Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family. Immunogenetics 53, 279-287 (2001).

Li, P., Morris, D.L., Willcox, B.E., Steinle, A., Spies, T. & Strong, R.K. Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA. Nature Immunology 2: 443-451 (2001).

 

1999

Bauer, S., Groh, V., Wu, J., Steinle, A., Philips, J. H., Lanier, L.L. & Spies T. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285, 727-729 (1999).

 

1998

Steinle, A., Groh, V. & Spies, T. Diversification, expression and gd T-cell recognition of evolutionary distant members of the MIC family of major histocompatibility complex class I-related molecules. Proceedings of the National Academy of Sciences USA 95, 12510-12515 (1998).

Groh, V., Steinle, A., Bauer, S. & Spies, T. Recognition of stress-induced MHC molecules by intestinal epithelial gd T cells. Science 279, 1737-1740 (1998).

 

1995

Falk, C.S., Steinle, A. & Schendel, D.J. Expression of HLA-C molecules confers target cell resistance to some non-major histocompatibility complex- restricted T cells in a manner analogous to allospecific natural killer cells. Journal of Experimental Medicine 182, 1005-1018 (1995).

Steinle, A., Reinhardt, C., Jantzer, P. & Schendel, D.J. In vivo expansion of HLA-B35 alloreactive T cells sharing homologous T cell receptors: evidence for maintenance of an oligoclonally dominated allospecificity by persistent stimulation with an autologous MHC/peptide complex. Journal of Experimental Medicine 181, 503-513 (1995).