PUBLICATIONS
2009
Vergne I, Roberts E, Elmaoued RA, Tosch V, Delgado MA, Proikas-Cezanne T, Laporte J, Deretic V.(2009) Control of autophagy initiation by phosphoinositide 3-phosphatase jumpy.
EMBO J., in press
Henneges C, Hinselmann G, Jung S, Madlung J, Schütz W, Nordheim A, Zell A. (2009). Ranking Methods for the Prediction of Frequent Top Scoring Peptides from Proteomics Data. J Proteomics & Bioinformatics 2, 226-235.
Stern S, Debre E, Stritt C, Berger J, Posern G, Knöll B. (2009). A nuclear actin function regulates neuronal motility by serum response factor-dependent gene transcription. J Neurosci. 29, 4512-4518.
Koegel H, von Tobel L, Schäfer M, Alberti S, Kremmer E, Mauch C, Hohl D, Wang XJ, Beer HD, Bloch W, Nordheim A, Werner S. (2009) Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice. J Clin Invest. 119, 899-910.
Stritt C, Stern S, Harting K, Manke T, Sinske D, Schwarz H, Vingron M, Nordheim A, Knöll B. (2009) Paracrine control of oligodendrocyte differentiation by SRF-directed neuronal gene expression. Nat Neurosci. 12, 418-427.
Saleem M, Lamkemeyer T, Schuetzenmeister A, Fladerer C, Piepho HP, Nordheim A, Hochholdinger F. (2009) Tissue specific control of the maize (Zea mays L.) embryo, cortical parenchyma, and stele proteomes by RUM1 which regulates seminal and lateral root initiation. J Proteome Res., Mar 7.
Sprossmann, F., Pankert, P., Sausbier, U., Wirth, A., Zhou, X. B., Madlung, J., Zhao, H., Bucurenciu, I., Jakob, A., Lamkemeyer, T., Neuhuber, W., Offermanns, S., Shipston, M. J., Korth, M., Nordheim, A., Ruth, P. & Sausbier, M. (2009). Inducible knockout mutagenesis reveals compensatory mechanisms elicited by constitutive BK channel deficiency in overactive murine bladder. FEBS J. 276, 1680-1697.
Barjaktarovic, Z., Schutz, W., Madlung, J., Fladerer, C., Nordheim, A. & Hampp, R. (2009). Changes in the effective gravitational field strength affect the state of phosphorylation of stress-related proteins in callus cultures of Arabidopsis thaliana. J Exp Bot. 60, 779-789.
Walker, T., Wendel, H. P., Raabe, C., Wyechnik, P., Spranger, L., Heidenreich, O., Scheule, A. M., Nordheim, A. & Ziemer, G. (2009). Graft Protection in Bypass Surgery: siRNA-Mediated Silencing of Adhesion Molecules. Oligonucleotide, in press
Proikas-Cezanne, T. & Pfisterer, S. G. (2009). Assessing mammalian autophagy by WIPI-1/Atg18 puncta formation. Methods Enzymol 452, 247-60.
Martinez Soria N., Tussiwand R., Ziegler P., Manz M. G., Heidenreich O. (2009). Transient depletion of RUNX1/RUNX1T1 by RNA interference delays tumour formation in vivo. Leukemia 23, 188-90.
2008
Berg T, Fliegauf M, Burger J, Staege MS, Liu S, Martinez N, Heidenreich O, Burdach S, Haferlach T, Werner MH, Lübbert M. (2008). Transcriptional upregulation of p21/WAF/Cip1 in myeloid leukemic blasts expressing AML1-ETO.Haematologica 93, 1728-33.
Duechting, A., Tschope, C., Kaiser, H., Lamkemeyer, T., Tanaka, N., Aberle, S., Lang, F., Torresi, J., Kandolf, R. & Bock, C. T. (2008). Human parvovirus B19 NS1 protein modulates inflammatory signaling by activation of STAT3/PIAS3 in human endothelial cells. J Virol 82, 7942-52.
Hala, M., Cole, R., Synek, L., Drdova, E., Pecenkova, T., Nordheim, A., Lamkemeyer, T., Madlung, J., Hochholdinger, F., Fowler, J. E. & Zarsky, V. (2008). An exocyst complex functions in plant cell growth in Arabidopsis and tobacco. Plant Cell 20, 1330-45.
Hoecker, N., Lamkemeyer, T., Sarholz, B., Paschold, A., Fladerer, C., Madlung, J., Wurster, K., Stahl, M., Piepho, H. P., Nordheim, A. & Hochholdinger, F. (2008). Analysis of nonadditive protein accumulation in young primary roots of a maize (Zea mays L.) F(1)-hybrid compared to its parental inbred lines. Proteomics 8, 3882-94.
Klionsky, D. J., Abeliovich, H., Agostinis, P., Agrawal, D. K., Aliev, G., Askew, D. S., Baba, M., .....plus multiple additional authors... Proikas-Cezanne, T., ......plus multiple additional authors..........et al. (2008). Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4, 151-75.
Meyer, V. S., Kastenmuller, W., Gasteiger, G., Franz-Wachtel, M., Lamkemeyer, T., Rammensee, H. G., Stevanovic, S., Sigurdardottir, D. & Drexler, I. (2008). Long-term immunity against actual poxviral HLA ligands as identified by differential stable isotope labeling. J Immunol 181, 6371-83.
Niu, Z., Iyer, D., Conway, S. J., Martin, J. F., Ivey, K., Srivastava, D., Nordheim, A. & Schwartz, R. J. (2008). Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart. Proc Natl Acad Sci U S A 105, 17824-9.
Petit, M. M., Lindskog, H., Larsson, E., Wasteson, P., Athley, E., Breuer, S., Angstenberger, M., Hertfelder, D., Mattsson, E., Nordheim, A., Nelander, S. & Lindahl, P. (2008). Smooth muscle expression of lipoma preferred partner is mediated by an alternative intronic promoter that is regulated by serum response factor/myocardin. Circ Res 103, 61-9.
Pirow, R., Buchen, I., Richter, M., Allmer, C., Nunes, F., Gunsel, A., Heikens, W., Lamkemeyer, T., von Reumont, B. M. & Hetz, S. K. (2008). Cationic composition and acid-base state of the extracellular fluid, and specific buffer value of hemoglobin from the branchiopod crustacean Triops cancriformis. J Comp Physiol [B].
Siemoneit, U., Hofmann, B., Kather, N., Lamkemeyer, T., Madlung, J., Franke, L., Schneider, G., Jauch, J., Poeckel, D. & Werz, O. (2008). Identification and functional analysis of cyclooxygenase-1 as a molecular target of boswellic acids. Biochem Pharmacol 75, 503-13.
Soskic, V., Klemm, M., Proikas-Cezanne, T., Schwall, G. P., Poznanovic, S., Stegmann, W., Groebe, K., Zengerling, H., Schoepf, R., Burnet, M. & Schrattenholz, A. (2008). A connection between the mitochondrial permeability transition pore, autophagy, and cerebral amyloidogenesis. J Proteome Res 7, 2262-9.
Pandithage, R., Lilischkis, R., Harting, K., Wolf, A., Jedamzik, B., Lüscher-Firzlaff, J., Vervoorts, J., Lasonder, E., Kremmer, E., Knöll, B., & Lüscher, B. (2008). The regulation of SIRT2 function by cyclin-dependent kinases affects cell motilit. J Cell Biol 180, 915-29.
2007
Angstenberger, M., Wegener, J. W., Pichler, B. J., Judenhofer, M. S., Feil, S., Alberti, S., Feil, R. & Nordheim, A. (2007). Severe intestinal obstruction on induced smooth muscle-specific ablation of the transcription factor SRF in adult mice. Gastroenterology 133, 1948-59.
Balabanov, S., Gontarewicz, A., Ziegler, P., Hartmann, U., Kammer, W., Copland, M., Brassat, U., Priemer, M., Hauber, I., Wilhelm, T., Schwarz, G., Kanz, L., Bokemeyer, C., Hauber, J., Holyoake, T. L., Nordheim, A. & Brümmendorf, T. H. (2007). Hypusination of eukaryotic initiation factor 5A (eIF5A): a novel therapeutic target in BCR-ABL-positive leukemias identified by a proteomics approach. Blood 109, 1701-11.
Barjaktarovic, Z., Nordheim, A., Lamkemeyer, T., Fladerer, C., Madlung, J. & Hampp, R. (2007). Time-course of changes in amounts of specific proteins upon exposure to hyper-g, 2-D clinorotation, and 3-D random positioning of Arabidopsis cell cultures. J Exp Bot 58, 4357-63.
Barth, M., Fischer, R., Brock, R. & Rademann, J. (2005). Reversible cross-linking of hyperbranched polymers: a strategy for the combinatorial decoration of multivalent scaffolds. Angew Chem Int Ed Engl 44, 1560-3.
Dembinsky, D., Woll, K., Saleem, M., Liu, Y., Fu, Y., Borsuk, L. A., Lamkemeyer, T., Fladerer, C., Madlung, J., Barbazuk, B., Nordheim, A., Nettleton, D., Schnable, P. S. & Hochholdinger, F. (2007). Transcriptomic and proteomic analyses of pericycle cells of the maize primary root. Plant Physiol 145, 575-88.
Duchardt, F., Fotin-Mleczek, M., Schwarz, H., Fischer, R. & Brock, R. (2007). A comprehensive model for the cellular uptake of cationic cell-penetrating peptides. Traffic 8, 848-66.
Elbs, M., Hulko, M., Frauenfeld, J., Fischer, R. & Brock, R. (2007). Multivalence and spot heterogeneity in microarray-based measurement of binding constants. Anal Bioanal Chem 387, 2017-25.
Fleige, A., Alberti, S., Grobe, L., Frischmann, U., Geffers, R., Muller, W., Nordheim, A. & Schippers, A. (2007). Serum response factor contributes selectively to lymphocyte development. J Biol Chem 282, 24320-8.
Klein, K., Tatzel, S., Raimundo, S., Saussele, T., Hustert, E., Pleiss, J., Eichelbaum, M. & Zanger, U. M. (2007). A natural variant of the heme-binding signature (R441C) resulting in complete loss of function of CYP2D6. Drug Metab Dispos 35, 1247-50.
Knöll, B., Weinl, C., Nordheim, A. & Bonhoeffer, F. (2007). Stripe assay to examine axonal guidance and cell migration. Nat Protoc 2, 1216-24.
Lianguzova, M. S., Chuykin, I. A., Nordheim, A. & Pospelov, V. A. (2007). Phosphoinositide 3-kinase inhibitor LY294002 but not serum withdrawal suppresses proliferation of murine embryonic stem cells. Cell Biol Int 31, 330-7.
Proikas-Cezanne, T., Ruckerbauer, S., Stierhof, Y. D., Berg, C. & Nordheim, A. (2007). Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy. FEBS Lett 581, 3396-404.
Radhika, V., Proikas-Cezanne, T., Jayaraman, M., Onesime, D., Ha, J. H. & Dhanasekaran, D. N. (2007). Chemical sensing of DNT by engineered olfactory yeast strain. Nat Chem Biol 3, 325-30.
Stoevesandt, O., Kohler, K., Wolf, S., Andre, T., Hummel, W. & Brock, R. (2007). A network analysis of changes in molecular interactions in cellular signaling. Mol Cell Proteomics 6, 503-13.
Voss, S., Fischer, R., Jung, G., Wiesmuller, K. H. & Brock, R. (2007). A fluorescence-based synthetic LPS sensor. J Am Chem Soc 129, 554-61.
Voss, S., Ulmer, A. J., Jung, G., Wiesmuller, K. H. & Brock, R. (2007). The activity of lipopeptide TLR2 agonists critically depends on the presence of solubilizers. Eur J Immunol 37, 3489-98.
Walker, T., Wendel, H. P., Tetzloff, L., Raabe, C., Heidenreich, O., Simon, P., Scheule, A. M. & Ziemer, G. (2007). Inhibition of adhesion molecule expression on human venous endothelial cells by non-viral siRNA transfection. J Cell Mol Med 11, 139-47.
2006
Berg, C. P., Stein, G. M., Klein, R., Pascu, M., Berg, T., Kammer, W., Priemer, M., Nordheim, A., Schulze-Osthoff, K., Gregor, M., Wesselborg, S. & Berg, P. A. (2006). Demonstration of PDC-E1 subunits as major antigens in the complement-fixing fraction M4 and re-evaluation of PDC-E1-specific antibodies in PBC patients. Liver Int 26, 846-55.
Buwitt-Beckmann, U., Heine, H., Wiesmuller, K. H., Jung, G., Brock, R., Akira, S. & Ulmer, A. J. (2006). TLR1- and TLR6-independent recognition of bacterial lipopeptides. J Biol Chem 281, 9049-57.
Carvalho, R. F., Beutler, M., Marler, K. J., Knoll, B., Becker-Barroso, E., Heintzmann, R., Ng, T. & Drescher, U. (2006). Silencing of EphA3 through a cis interaction with ephrinA5. Nat Neurosci 9, 322-30.
Dunne, J., Cullmann, C., Ritter, M., Soria, N. M., Drescher, B., Debernardi, S., Skoulakis, S., Hartmann, O., Krause, M., Krauter, J., Neubauer, A., Young, B. D. & Heidenreich, O. (2006). siRNA-mediated AML1/MTG8 depletion affects differentiation and proliferation-associated gene expression in t(8;21)-positive cell lines and primary AML blasts. Oncogene 25, 6067-78.
Etkin, A., Alarcon, J. M., Weisberg, S. P., Touzani, K., Huang, Y. Y., Nordheim, A. & Kandel, E. R. (2006). A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context. Neuron 50, 127-43.
Fischer, R., Bachle, D., Fotin-Mleczek, M., Jung, G., Kalbacher, H. & Brock, R. (2006). A targeted protease substrate for a quantitative determination of protease activities in the endolysosomal pathway. Chembiochem 7, 1428-34.
Heeren A., Luo C.-P., Roth G., Ganser A., Brock R., Wiesmüller K.-H., Henschel W., Kern D.P. (2006). Diffusion along microfluidic channels, Microelectron. Eng. 83, 1669-1672.
Knöll, B., Kretz, O., Fiedler, C., Alberti, S., Schutz, G., Frotscher, M. & Nordheim, A. (2006). Serum response factor controls neuronal circuit assembly in the hippocampus. Nat Neurosci 9, 195-204.
Knöll, B., and A. Nordheim. 2006. The roles of Serum Response Factor (SRF) in Development and Function of the Brain. In: Transcription Factors. Ed. G. Thiel. WILEY-VCH. Weinheim.
Lianguzova, M. S., Chuikin, I. A., Nordheim, A. & Pospelov, V. A. (2006). [PI3-kinase inhibitors LY294002 and wortmannin have different effects on proliferation of murine embryonic stem cells]. Tsitologiia 48, 560-8.
Lindner, L. H., Brock, R., Arndt-Jovin, D. & Eibl, H. (2006). Structural variation of cationic lipids: minimum requirement for improved oligonucleotide delivery into cells. J Control Release 110, 444-56.
Liu, Y., Lamkemeyer, T., Jakob, A., Mi, G., Zhang, F., Nordheim, A. & Hochholdinger, F. (2006). Comparative proteome analyses of maize (Zea mays L.) primary roots prior to lateral root initiation reveal differential protein expression in the lateral root initiation mutant rum1. Proteomics 6, 4300-8.
Mohrle, B. P., Kohler, K., Jaehrling, J., Brock, R. & Gauglitz, G. (2006). Label-free characterization of cell adhesion using reflectometric interference spectroscopy (RIfS). Anal Bioanal Chem 384, 407-13.
Mordmuller, B., Fendel, R., Kreidenweiss, A., Gille, C., Hurwitz, R., Metzger, W. G., Kun, J. F., Lamkemeyer, T., Nordheim, A. & Kremsner, P. G. (2006). Plasmodia express two threonine-peptidase complexes during asexual development. Mol Biochem Parasitol 148, 79-85.
Neubauer, H., Clare, S. E., Kurek, R., Fehm, T., Wallwiener, D., Sotlar, K., Nordheim, A., Wozny, W., Schwall, G. P., Poznanovic, S., Sastri, C., Hunzinger, C., Stegmann, W., Schrattenholz, A. & Cahill, M. A. (2006). Breast cancer proteomics by laser capture microdissection, sample pooling, 54-cm IPG IEF, and differential iodine radioisotope detection. Electrophoresis 27, 1840-52.
Oehler S, Alberti S, Muller-Hill B. (2006) Induction of the lac promoter in the absence of DNA loops and the stoichiometry of induction. Nucleic Acids Res. 34: 606-12.
Proikas-Cezanne, T., Gaugel, A., Frickey, T. & Nordheim, A. (2006). Rab14 is part of the early endosomal clathrin-coated TGN microdomain. FEBS Lett 580, 5241-6.
Resch, A., Leicht, S., Saric, M., Pasztor, L., Jakob, A., Gotz, F. & Nordheim, A. (2006). Comparative proteome analysis of Staphylococcus aureus biofilm and planktonic cells and correlation with transcriptome profiling. Proteomics 6, 1867-77.
Ronnefarth, V. M., Erbacher, A. I., Lamkemeyer, T., Madlung, J., Nordheim, A., Rammensee, H. G. & Decker, P. (2006). TLR2/TLR4-independent neutrophil activation and recruitment upon endocytosis of nucleosomes reveals a new pathway of innate immunity in systemic lupus erythematosus. J Immunol 177, 7740-9.
Sauer, M., Jakob, A., Nordheim, A. & Hochholdinger, F. (2006). Proteomic analysis of shoot-borne root initiation in maize (Zea mays L.). Proteomics 6, 2530-41.
Seyberth, T., Voss, S., Brock, R., Wiesmuller, K. H. & Jung, G. (2006). Lipolanthionine peptides act as inhibitors of TLR2-mediated IL-8 secretion. Synthesis and structure-activity relationships. J Med Chem 49, 1754-65.
Stoevesandt, O., Kohler, K., Wolf, S., Andre, T., Hummel, W. & Brock, R. (2006). A network analysis of changes in molecular interactions in cellular signaling. Mol Cell Proteomics.
Stoevesandt, O., Brock, R. (2006). One-step analysis of protein complexes in microliters of cell lysate using indirect immunolabeling and fluorescence cross-correlation spectroscopy, Nature Protocols 1, 223 229.
Thomas, M., Greil, J. & Heidenreich, O. (2006). Targeting leukemic fusion proteins with small interfering RNAs: recent advances and therapeutic potentials. Acta Pharmacol Sin 27, 273-81.
Toscano C, Raimundo S, Klein K, Eichelbaum M, Schwab M, Zanger UM. (2006).A silent mutation (2939G>A, exon 6; CYP2D6*59) leading to impaired expression and function of CYP2D6.
Pharmacogenet Genomics. 16(10):767-70.
Toscano C, Klein K, Blievernicht J, Schaeffeler E, Saussele T, Raimundo S, Eichelbaum M, Schwab M, Zanger UM. (2006). Impaired expression of CYP2D6 in intermediate metabolizers carrying the *41 allele caused by the intronic SNP 2988G>A: evidence for modulation of splicing events. Pharmacogenet Genomics.16(10):755-66
Voss, S., Welte, S., Fotin-Mleczek, M., Fischer, R., Ulmer, A. J., Jung, G., Wiesmuller, K. H. & Brock, R. (2006). A CD14 domain with lipopolysaccharide-binding and -neutralizing activity. Chembiochem 7, 275-86.
Zimmermann, U., Junker, H., Kramer, F., Balabanov, S., Kleist, B., Kammer, W., Nordheim, A. & Walther, R. (2006). Comparative proteomic analysis of neoplastic and non-neoplastic germ cell tissue. Biol Chem 387, 437-40.
2005
Alberti, S., Krause, S. M., Kretz, O., Philippar, U., Lemberger, T., Casanova, E., Wiebel, F. F., Schwarz, H., Frotscher, M., Schütz, G. and Nordheim, A. (2005). Neuronal migraation in the rostral migratory stream requires serum response factor. Proc Natl Acad Sci U S A 102, 6148-6153.
Li, S., Czubryt, M. P., McAnally, J., Bassel-Duby, R., Richardson, J. A., Wiebel, F. F., Nordheim, A., and Olson, E. N. (2005). Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice. Proc Natl Acad Sci U S A 102, 1082-1087.
Neugebauer, H., Herrmann, C., Kammer, W., Schwarz, G., Nordheim, A., and Braun, V. (2005). ExbBD-dependent transport of maltodextrins through the novel MalA protein across the outer membrane of Caulobacter crescentus. J Bacteriol 187, 8300-8311.
Niu, Z., Yu, W., Zhang, S. X., Barron, M., Belaguli, N. S., Schneider, M. D., Parmacek, M., Nordheim, A., and Schwartz, R. J. (2005). Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets. J Biol Chem 280, 32531-32538.
Hennersdorf, F., Florian, S., Jakob, A., Baumgartner, K., Sonneck, K., Nordheim, A., Biedermann, T., Valent, P., and Buhring, H. J. (2005). Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of ige-dependent upregulation. Cell Res 15, 325-335.
Junker, H., Spate, K., Suofu, Y., Walther, R., Schwarz, G., Kammer, W., Nordheim, A., Walker, L. C., Runge, U., Kessler, C., and Popa-Wagner, A. (2005). Proteomic identification of the involvement of the mitochondrial rieske protein in epilepsy. Epilepsia 46, 339-343.
Buwitt-Beckmann, U., Heine, H., Wiesmüller, K.-H., Jung, G., Brock, R., Akira, S., Ulmer, A. J. (2005). Toll-like receptor 6-independent signaling of diacylated lipopeptides, Eur. J. Immunol. 35, 282-289.
Lellouch, A. C., Vollmer, S., Hoff, A., Peters L., Rogl, H., Malissen, B., Brock, R. (2005). Chemical inhibitors when timing is critical: A pharmacological concept for the maturation of T cell contacts, ChemBioChem 6, 152-161.
John, M., Geick, A., Hadwiger, P., Vornlocher, H.-P., and Heidenreich, O. (2005). Gene silencing methods for mammalian cells: application of synthetic siRNAs. In Handbook of RNA Biochemistry, R. Hartmann, ed. (Weinheim, Wiley VCH).
Baechle, D., Fischer, R., Cansier, A., Brock, R., and Kalbacher, H. (2005). A postcolumn alkalinization procedure enhances the sensitivity of fluorescence detection of fluorescein-labeled substances in RP-HPLC. Anal Biochem 345, 161-163.
Barth, M., Fischer, R., Brock, R., and Rademann, J. (2005). Reversible cross-linking of hyperbranched polymers: a strategy for the combinatorial decoration of multivalent scaffolds. Angew Chem Int Ed Engl 44, 1560-1563.
Dengjel, J., Schoor, O., Fischer, R., Reich, M., Kraus, M., Muller, M., Kreymborg, K., Altenberend, F., Brandenburg, J., Kalbacher, H., et al. (2005). Autophagy promotes MHC class II presentation of peptides from intracellular source proteins. Proc Natl Acad Sci U S A 102, 7922-7927.
Fischer, R., Fotin-Mleczek, M., Hufnagel, H., and Brock, R. (2005). Break on through to the other side-biophysics and cell biology shed light on cell-penetrating peptides. Chembiochem 6, 2126-2142.
Fotin-Mleczek, M., Fischer, R., and Brock, R. (2005a). Endocytosis and cationic cell-penetrating peptides--a merger of concepts and methods. Curr Pharm Des 11, 3613-3628.
Fotin-Mleczek, M., Welte, S., Mader, O., Duchardt, F., Fischer, R., Hufnagel, H., Scheurich, P., and Brock, R. (2005b). Cationic cell-penetrating peptides interfere with TNF signalling by induction of TNF receptor internalization. J Cell Sci 118, 3339-3351.
Kohler, K., Lellouch, A. C., Vollmer, S., Stoevesandt, O., Hoff, A., Peters, L., Rogl, H., Malissen, B., and Brock, R. (2005). Chemical inhibitors when timing is critical: a pharmacological concept for the maturation of T cell contacts. Chembiochem 6, 152-161.
Radhika, V., Milkevitch, M., Audige, V., Proikas-Cezanne, T., and Dhanasekaran, N. (2005). Engineered Saccharomyces cerevisiae strain BioS-1, for the detection of water-borne toxic metal contaminants. Biotechnol Bioeng 90, 29-35.
Rashid, T., Upton, A. L., Blentic, A., Ciossek, T., Knoll, B., Thompson, I. D., and Drescher, U. (2005). Opposing gradients of ephrin-As and EphA7 in the superior colliculus are essential for topographic mapping in the mammalian visual system. Neuron 47, 57-69.
Stoevesandt, O., Elbs, M., Kohler, K., Lellouch, A. C., Fischer, R., Andre, T., and Brock, R. (2005a). Peptide microarrays for the detection of molecular interactions in cellular signal transduction. Proteomics 5, 2010-2017.
Stoevesandt, O., Kohler, K., Fischer, R., Johnston, I. C., and Brock, R. (2005b). One-step analysis of protein complexes in microliters of cell lysate. Nat Methods 2, 833-835.
Thomas, M., Gessner, A., Vornlocher, H. P., Hadwiger, P., Greil, J., and Heidenreich, O. (2005). Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells. Blood 106, 3559-3566.
Walker, T., Wendel, H. P., Tetzloff, L., Heidenreich, O., and Ziemer, G. (2005). Suppression of ICAM-1 in human venous endothelial cells by small interfering RNAs. Eur J Cardiothorac Surg 28, 816-820.
2004
Philippar, U., Schratt, G., Dieterich, C., Muller, J. M., Galgoczy, P., Engel, F. B., Keating, M. T., Gertler, F., Schule, R., Vingron, M., and Nordheim, A. (2004). The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF. Mol Cell 16, 867-880.
Proikas-Cezanne, T., Waddell, S., Gaugel, A., Frickey, T., Lupas, A., and Nordheim, A. (2004). WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy. Oncogene 23, 9314-9325.
Cesari, F., Brecht, S., Vintersten, K., Vuong, L. G., Hofmann, M., Klingel, K., Schnorr, J. J., Arsenian, S., Schild, H., Herdegen, T., et al. (2004a). Mice deficient for the ets transcription factor elk-1 show normal immune responses and mildly impaired neuronal gene activation. Mol Cell Biol 24, 294-305.
Cesari, F., Rennekampff, V., Vintersten, K., Vuong, L. G., Seibler, J., Bode, J., Wiebel, F. F., and Nordheim, A. (2004b). Elk-1 knock-out mice engineered by Flp recombinase-mediated cassette exchange. Genesis 38, 87-92.
Lautwein, A., Kraus, M., Reich, M., Burster, T., Brandenburg, J., Overkleeft, H. S., Schwarz, G., Kammer, W., Weber, E., Kalbacher, H., et al. (2004). Human B lymphoblastoid cells contain distinct patterns of cathepsin activity in endocytic compartments and regulate MHC class II transport in a cathepsin S-independent manner. J Leukoc Biol 75, 844-855.
Schill, R., Steinbrück, G. H. B., and Köhler, H.-R. (2004). Stress gene (hsp70) sequences and quantitative expression in Milnesium tardigradum (Tardigrada) during active and cryptobiotic stages. J. Exp. Biol. 207, 1607-1613.
Martinez, N., Drescher, B., Riehle, H., Cullmann, C., Vornlocher, H. P., Ganser, A., Heil, G., Nordheim, A., Krauter, J., and Heidenreich, O. (2004). The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells. BMC Cancer 4, 44.
Bockhardt, A., and Heidenreich, O. (2004). RNA interference as a potential tool in the treatment of leukaemia. Expert Opin Biol Ther 4, 1921-1929.
Heidenreich, O. (2004). Oncogene suppression by small interfering RNAs. Curr Pharm Biotechnol 5, 349-354.
Riess, T., Andersson, S. G., Lupas, A., Schaller, M., Schafer, A., Kyme, P., Martin, J., Walzlein, J. H., Ehehalt, U., Lindroos, H., et al. (2004). Bartonella adhesin a mediates a proangiogenic host cell response. J Exp Med 200, 1267-1278.
Schratt, G., Philippar, U., Hockemeyer, D., Schwarz, H., Alberti, S., and Nordheim, A. (2004). SRF regulates Bcl-2 expression and promotes cell survival during murine embryonic development. Embo J 23, 1834-1844.
Wang, Z., Wang, D. Z., Hockemeyer, D., McAnally, J., Nordheim, A., and Olson, E. N. (2004). Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. Nature 428, 185-189.
Mader, O., Reiner, K., Egelhaaf, H.-J., Fischer, R., Brock, R. (2004). Structure-property analysis of pentamethine indocyanine dyes identification of a new dye for life-science applications, Bioconjugate Chem. 15, 70-78
Fischer, R., Köhler, K., Fotin-Mleczek, M., Brock, R. (2004). A stepwise dissection of the intracellular fate of cationic cell-penetrating peptides, J. Biol. Chem. 279, 12625-12635.
Spohn, R., Buwitt-Beckmann, U., Brock, R., Jung, G., Ulmer, A. J., and Wiesmüller, K.-H. (2004). Synthetic lipopeptide adjuvants and Toll-like receptor 2 - Structure-activity relationships, Vaccine 22, 2494-2499.
Hoff, A., André T., Fischer, R., Hulko, M., Marquardt, U., Wiesmüller, K.-H., Brock, R. (2004), Chemolabile cellular microarrays for the screening of small compounds and peptides, Molecular Diversity 8, 311-320.
Raimundo S, Toscano C, Klein K, Fischer J, Griese EU, Eichelbaum M, Schwab M, Zanger UM. (2004)A novel intronic mutation, 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects. Clin Pharmacol Ther. 76, 128-38.
Zanger UM, Raimundo S, Eichelbaum M. (2004) Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry. Naunyn Schmiedebergs Arch Pharmacol. 369, 23-37.
2003
Schuck, S., Soloaga, A., Schratt, G., Arthur, J. S., and Nordheim, A. (2003). The kinase MSK1 is required for induction of c-fos by lysophosphatidic acid in mouse embryonic stem cells. BMC Mol Biol 4, 6.
Lindemann, R. K., Nordheim, A., and Dittmer, J. (2003). Interfering with TGFbeta-induced Smad3 nuclear accumulation differentially
affects TGFbeta-dependent gene expression. Molecular Cancer 2, 10 pages.
Lindemann, R. K., Braig, M., Hauser, C. A., Nordheim, A., and Dittmer, J. (2003). Ets2 and protein kinase C-epsilon are important regulators of parathyroid hormone-related protein expression in MCF-7 breast cancer cells. Biochem J 372, 787-797.
Lindemann, R. K., Braig, M., Ballschmieter, P., Guise, T. A., Nordheim, A., and Dittmer, J. (2003). Protein kinase Calpha regulates Ets1 transcriptional activity in invasive breast cancer cells. Int J Oncol 22, 799-805.
Heidenreich, O., Krauter, J., Riehle, H., Hadwiger, P., John, M., Heil, G., Vornlocher, H., and Nordheim, A. (2003). AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive leukemic cells. Blood 15;101, 3157-3163.
Ballschmieter, P., Braig, M., Lindemann, R. K., Nordheim, A., and Dittmer, J. (2003). Splicing variant DeltaVII-Ets1 is downregulated in invasive Ets1-expressing breast cancer cells. Int J Oncol 22, 849-853.
Brock, R., Jovin, T. (2003). Quantitative Image Analysis of Cellular Protein Translocation Induced by Magnetic Microspheres: Application to the EGF Receptor, Cytometry 52, 1-11.
Fischer, R., Mader, O., Jung, G., Brock, R. (2003). Extending the applicability of carboxyfluorescein in solid-phase synthesis, Bioconjugate Chem. 14, 653-660.
Kim, B. H., Mader, O.,Weimar, U., Brock, R., Kern, D. P. (2003). Detection of biomolecules using microcantilevers as surface stress sensors, J. Vacuum Science and Technology B, J. Vac. Sci. Technol. B 21, 1472-1475.
Elbs, M., Brock, R. (2003). Determination of binding constants on microarrays with confocal fluorescence detection, Anal. Chem., 75, 4793-4800.
Meuth, S. G., Budde, T., Duyar, H., Landgraf, P., Broicher, T., Elbs, M., Brock, R., Weller, M., Weissert, R., Wiendl, H. (2003). Modulation of neuronal activity by the pentapeptide QYNAD Eur. J. Neurosc. 18, 1-10
Dunne, J., Drescher, B., Riehle, H., Hadwiger, P., Young, B. D., Krauter, J., and Heidenreich, O. (2003). The apparent uptake of fluorescently labeled siRNAs by electroporated cells depends on the fluorochrome. Oligonucleotides 13, 375-380.
Heidenreich, O. (2003). siRNAs: magic bullets for functional genomics and therapy? Eur Pharm Rev 8, 19-27.
John, M., Geick, A., Hadwiger, P., Vornlocher, H. P., and Heidenreich, O. (2003). Gene silencing by RNAi in mammalian cells. In Current protocols in molecular biology, F. M. Ausubel, B. Brent , R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl, eds. (New York, John Wiley & Sons), pp. 26.22.21-26.22.14.
Scherr, M., Battmer, K., Winkler, T., Heidenreich, O., Ganser, A., and Eder, M. (2003). Specific inhibition of bcr-abl gene expression by small interfering RNA. Blood 101, 1566-1569.
2002
Wiebel, F. F., Rennekampff, V., Vintersten, K., and Nordheim, A. (2002). Generation of mice carrying conditional knockout alleles for the transcription factor SRF. Genesis 32, 124-126.
Wang, D. Z., Li, S., Hockemeyer, D., Sutherland, L., Wang, Z., Schratt, G., Richardson, J. A., Nordheim, A., and Olson, E. N. (2002). Potentiation of serum response factor activity by a family of myocardin-related transcription factors. Proc Natl Acad Sci U S A 99, 14855-14860.
Schratt, G., Philippar, U., Berger, J., Schwarz, H., Heidenreich, O., and Nordheim, A. (2002). Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells. J Cell Biol 156, 737-750.
Kuprash, D. V., Boitchenko, V. E., Yarovinsky, F. O., Rice, N. R., Nordheim, A., Ruhlmann, A., and Nedospasov, S. A. (2002). Cyclosporin A blocks the expression of lymphotoxin alpha, but not lymphotoxin beta, in human peripheral blood mononuclear cells. Blood 100, 1721-1727.
Waizenegger, T., Fischer, R., Brock, R. (2002). Intracellular concentration measurements in adherent tissue culture cells A comparison of cell permeable peptides. Biol. Chem. 383, 291-299.
Fischer, R., Waizenegger, T., Köhler, K., Brock, R. (2002). A quantitative validation of fluorophore-labelled cell-permeable peptide conjugates: Fluorophore and cargo dependence of import. Biochim. Biophys. Acta 1564, 365-374.
Hoff, A., André, T., Schäffer, T. E., Jung, G., Wiesmüller, K. H., Brock, R. (2002). Lipoconjugates for the non covalent generation of microarrays in biochemical and cellular assays. ChemBioChem 3, 1183-1191.
Nagel, S., Hambach, L., Krauter, J., Venturini, L., Heidenreich, O., Ganser, A., and Heil, G. (2002). Analysis of the Nuclear Distribution of the Translocation t(8;21)-Derived Fusion Protein AML1/ETO by Confocal Laser Scanning Microscopy. J Hematother Stem Cell Res 11, 401-408.
2001
Szyrach, M., Munchberg, F. E., Riehle, H., Nordheim, A., Krauter, J., Nagel, S., Heil, G., and Heidenreich, O. (2001). Cleavage of AML1/MTG8 by asymmetric hammerhead ribozymes. Eur J Biochem 268, 3550-3557.
Schratt, G., Weinhold, B., Lundberg, A. S., Schuck, S., Berger, J., Schwarz, H., Weinberg, R. A., Ruther, U., and Nordheim, A. (2001). Serum response factor is required for immediate-early gene activation yet is dispensable for proliferation of embryonic stem cells. Mol Cell Biol 21, 2933-2943.
Nentwich, O., Munchberg, F. E., Frommer, G., and Nordheim, A. (2001). Tissue-specific expression of the Ets gene Xsap-1 during Xenopus laevis development. Mech Dev 109, 433-436.
Lindemann, R. K., Ballschmieter, P., Nordheim, A., and Dittmer, J. (2001). Transforming growth factor beta regulates parathyroid hormone-related protein expression in MDA-MB-231 breast cancer cells through a novel Smad/Ets synergism. J Biol Chem 276, 46661-46670.
Boitchenko, V., Kuprash, D., Nordheim, A., Ruhlmann, A., and Nedospasov, S. (2001). Cyclosporin A Blocks PMA and Ionomycin Activated Lymphotoxin Expression in a
Human T-Cell Line. Russ J Immunol 6, 9-16.
Krauter, J., Hoellge, W., Wattjes, M. P., Nagel, S., Heidenreich, O., Bunjes, D., Ganser, A., and Heil, G. (2001). Detection and quantification of CBFB/MYH11 fusion transcripts in patients with inv(16)-positive acute myeloblastic leukemia by real-time RT-PCR. Genes Chromosomes Cancer 30, 342-348.
2000
White, C. M., Heidenreich, O., Nordheim, A., and Beerman, T. A. (2000). Evaluation of the effectiveness of DNA-binding drugs to inhibit transcription using the c-fos serum response element as a target. Biochemistry 39, 12262-12273.
Weinhold, B., Schratt, G., Arsenian, S., Berger, J., Kamino, K., Schwarz, H., Ruther, U., and Nordheim, A. (2000). Srf(-/-) ES cells display non-cell-autonomous impairment in mesodermal differentiation. Embo J 19, 5835-5844.
Vuong, G. L., Weiss, S. M., Kammer, W., Priemer, M., Vingron, M., Nordheim, A., and Cahill, M. A. (2000). Improved sensitivity proteomics by postharvest alkylation and radioactive labelling of proteins. Electrophoresis 21, 2594-2605.
1999
Lehmann, U., Brocke, P., Dittmer, J., and Nordheim, A. (1999). Characterization of the human elk-1 promoter. Potential role of a downstream intronic sequence for elk-1 gene expression in monocytes. J Biol Chem 274, 1736-1744.
Kreideweiss, S., Ahlers, C., Nordheim, A., and Ruhlmann, A. (1999). Ca2+-induced p38/SAPK signalling inhibited by the immunosuppressant cyclosporin A in human peripheral blood mononuclear cells. Eur J Biochem 265, 1075-1084.
Krain, B., and Nordheim, A. (1999). Artefactual gene induction during preparation of Xenopus laevis animal cap explants. Int J Dev Biol 43, 563-566.
Hollnagel, A., Oehlmann, V., Heymer, J., Ruther, U., and Nordheim, A. (1999). Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. J Biol Chem 274, 19838-19845.
Heidenreich, O., Neininger, A., Schratt, G., Zinck, R., Cahill, M. A., Engel, K., Kotlyarov, A., Kraft, R., Kostka, S., Gaestel, M., and Nordheim, A. (1999). MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo. J Biol Chem 274, 14434-14443.
Blumenthal, S. G., Aichele, G., Wirth, T., Czernilofsky, A. P., Nordheim, A., and Dittmer, J. (1999). Regulation of the human interleukin-5 promoter by Ets transcription factors. Ets1 and Ets2, but not Elf-1, cooperate with GATA3 and HTLV-I Tax1. J Biol Chem 274, 12910-12916.
Ahlers, C., Kreideweiss, S., Nordheim, A., and Ruhlmann, A. (1999). Cyclosporin A inhibits Ca2+-mediated upregulation of the DNA repair enzyme DNA polymerase beta in human peripheral blood mononuclear cells. Eur J Biochem 264, 952-959.
1998
Panitz, F., Krain, B., Hollemann, T., Nordheim, A., and Pieler, T. (1998). The Spemann organizer-expressed zinc finger gene Xegr-1 responds to the MAP kinase/Ets-SRF signal transduction pathway. Embo J 17, 4414-4425.
Dittmer, J., and Nordheim, A. (1998). Ets transcription factors and human disease. Biochim Biophys Acta 1377, F1-11.
Arsenian, S., Weinhold, B., Oelgeschlager, M., Ruther, U., and Nordheim, A. (1998). Serum response factor is essential for mesoderm formation during mouse embryogenesis. Embo J 17, 6289-6299.
1997
Ruhlmann, A., and Nordheim, A. (1997). Effects of the immunosuppressive drugs CsA and FK506 on intracellular signalling and gene regulation. Immunobiology 198, 192-206.
Muller, J. M., Cahill, M. A., Rupec, R. A., Baeuerle, P. A., and Nordheim, A. (1997). Antioxidants as well as oxidants activate c-fos via Ras-dependent activation of extracellular-signal-regulated kinase 2 and Elk-1. Eur J Biochem 244, 45-52.
Malek, N. P., Casper, J., Looijenga, L. H., Strohmeyer, T., Schmoll, H. J., Nordheim, A., and Janknecht, R. (1997). Quantification of additional short arms of chromosome 12 in germ cell tumours using the polymerase chain reaction. Eur J Cancer 33, 1488-1494.
Herrera, R. E., Nordheim, A., and Stewart, A. F. (1997). Chromatin structure analysis of the human c-fos promoter reveals a centrally positioned nucleosome. Chromosoma 106, 284-292.
Bredemeier-Ernst, I., Nordheim, A., and Janknecht, R. (1997). Transcriptional activity and constitutive nuclear localization of the ETS protein Elf-1. FEBS Lett 408, 47-51.
1996
Muller, J. M., Cahill, M. A., Nordheim, A., and Baeuerle, P. A. (1996). The transcription factor TCF/Elk-1: a nuclear sensor of changes in the cellular redox status. Adv Exp Med Biol 387, 77-84.
Janknecht, R., and Nordheim, A. (1996). Regulation of the c-fos promoter by the ternary complex factor Sap-1a and its coactivator CBP. Oncogene 12, 1961-1969.
Janknecht, R., and Nordheim, A. (1996). MAP kinase-dependent transcriptional coactivation by Elk-1 and its cofactor CBP. Biochem Biophys Res Commun 228, 831-837.
Cahill, M. A., Janknecht, R., and Nordheim, A. (1996). Signalling pathways: jack of all cascades. Curr Biol 6, 16-19.
Cahill, M. A., Peter, M. E., Kischkel, F. C., Chinnaiyan, A. M., Dixit, V. M., Krammer, P. H., and Nordheim, A. (1996). CD95 (APO-1/Fas) induces activation of SAP kinases downstream of ICE-like proteases. Oncogene 13, 2087-2096.
Cahill, M. A., Nordheim, A., and Xu, Y. Z. (1996). Crosslinking of SRF to the c-fos SRE CArG box guanines using photo-active thioguanine oligodeoxynucleotides. Biochem Biophys Res Commun 229, 170-175.