Pharmaceutical and Medicinal Chemistry

Veröffentlichungen J.E. Schultz

Publications (since 2006)

  1. E. Beitz, B. Wu, L. M. Holm, J.E. Schultz, T. Zeuthen (2006) Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia and protons. Proc. Natl. Acad. Sci. USA 103:269-274.
  2. S. Pavlovic-Djuranovic, J. F. J. Kun, J.E. Schultz, E. Beitz (2006) Dihydroxyacetone and methylglyoxal as permeants of the Plasmodium aquaglyceroporin inhibit parasite proliferation. Biochim. Biophys. Acta 1758, 1012-1017
  3. M. Gross-Langenhoff, K. Hofbauer, J. Weber, A. Schultz, J.E. Schultz (2006) cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11. J. Biol. Chem. 281:2841-2846
  4. S. Bruder, A. Schultz, J.E. Schultz (2006) Characterization of the tandem GAF domain from human phosphodiesterase 5 using a cyanobacterial adenylyl cyclase as a reporter enzyme. J. Biol. Chem. 281:19969-19976.
  5. M. Hulko, F. Berndt, M. Gruber, J.U. Linder, V. Truffault, A. Schultz, J. Martin, J.E. Schultz, A.N. Lupas, M. Coles (2006) The HAMP domain structure implies helix rotation in transmembrane signalling. Cell 126:929-940.
  6. D. Dittrich, C. Keller, S. Ehlers, J.E. Schultz, P. Sander (2006) Characterization of a Mycobacterium tuberculosis mutant deficient in pH-sensing adenylate cyclase Rv1264. Int. J. of Med. Microbiol. 296:563-566.
  7. T. Zeuthen, B. Wu, S. Pavlovic-Djuranovic, L. M. Holm, N.L. Uzcategui, M. Duszenko, J.F.J. Kun, J.E. Schultz, E. Beitz (2006) Ammonia permeability of the aquaglyceroporins from Plasmodium falciparum, Toxoplasma gondii and Trypansoma brucei. Mol. Microbiol. 61, 1598-1608.
  8. A. Abdel Motaal, I. Tews, J.E. Schultz, Jürgen U. Linder (2006) Fatty acid regulation of adenylyl cyclase Rv2212 from Mycobacterium tuberculosis H37Rv. FEBS J. 273:4219-4228.
  9. J.U. Linder, S. Bruder, A. Schultz, J.E. Schultz (2007) Changes in purine specificity in tandem GAF chimeras from cyanobacterial cyaB1 adenylyl cyclase and rat phosphodiesterase 2. FEBS J. 274:1514-1523.
  10. F. Findeisen, J.U. Linder, A. Schultz, J.E. Schultz, B. Brügger, F. Wieland, I. Sinning, I. Tews (2007) The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid. J. Mol. Biol. 369:1282-1295.
  11. M. Gross-Langenhoff, A. Stenzl, F. Altenberend, A. Schultz, J.E. Schultz (2008) The properties of phosphodiesterase 11A4 GAF domains are regulated by modifications in its N-terminal domain. FEBS J. 275:1643-1650.
  12. K. Hofbauer, A. Schultz,. J.E. Schultz. (2008) Functional Chimeras of the Phosphodiesterase 5 and 10 Tandem GAF Domains. J.Biol.Chem. 283:25164-25170.
  13. Linder J.U., Schultz J.E. (2008) Versatility of Signal Transduction Encoded in Dimeric Adenylyl Cyclases. Curr. Opinion Struct. Biol. 18:667–672
  14. Schultz J.E. (2009) Structural and Biochemical Aspects of Tandem GAF domains. in Handbook Exptl. Pharmacol. 191 (H.H.H.W. Schmidt et al. eds., cGMP: Generators, Effectors and Therapeutic Implications, Springer-Verlag Berlin Heidelberg) pp. 93-109
  15. Guo Y.L., Mayer H., Vollmer W., Dittrich D., Sander P., Schultz A., Schultz J.E. (2009) Polyphosphates from Mycobacterium bovis: potent inhibitors of class III adenylate cyclases. FEBS J. 276:1094–110
  16. Linder J.U., Schultz J.E. (2009) Use of Chimeric Adenylyl Cyclases to Study Cyclic Nucleotide Signaling. In: Handbook of Cell Signaling (R.A. Bradshaw and E. A. Dennis, eds., 2nd edition. Oxford: Academic Press, 2009) pp. 1537-1542.
  17. Kanchan K., Linder J.U., Winkler K., Hantke K., Schultz A., Schultz J.E. (2010) Transmembrane signaling in chimeras of the Escherichia coli aspartate and serine chemotaxis receptors and bacterial class III adenylyl cyclases J. Biol. Chem. 285:2090-2099.
  18. Linder J.U., Schultz J.E. (2010) HAMP Domain Adenylyl Cyclase Chimeras. Transmembrane receptor chimeras to probe HAMP domain function. Meth. Enzymol. 471:115-123.
  19. Schultz, J.E., Dunkern, T., Gawlitta-Gorka, E., Sorg G. (2011) The Regulatory GAF-tandem domain of Phosphodiesterase 5 is a Potential Drug Target. in Handbook Exptl. Pharmacol. 204:151-166.
  20. Hantke, K., Winkler, K., Schultz, J.E. (2011) Escherichia coli Exports Cyclic AMP via TolC. J. Bacteriol. 193:1086-1089.
  21. Ferris, H.U., Dunin-Horkawicz, S., Garcia Mondéjar, L., Hulko, M., Hantke, K., Martin, J., Schultz, J.E., Zeth, K., Lupas, A.N., Coles, M. (2011) The Mechanisms of HAMP-Mediated Signaling in Transmembrane Receptors. Structure
  22. Banjac, A., Zimmermann, M.O., Boeckler, F.M., Kurz, U., Schultz, A., Schultz J.E. (2012) Intramolecular signaling in tandem-GAF domains from PDE5 and PDE10 studied with a cyanobacterial adenylyl cyclase reporter. Cell. Sign. 24:629-634.
  23. Hedda U Ferris, H.U.; Dunin-Horkawicz, S.; Hornig, N.; Hulko, M.; Martin, J.; Schultz; J.E., Zeth, K., Lupas, A.N.; Coles, M. (2012) Mechanism of Regulation of Receptor Histidine Kinases. Structure 20:56-66.
  24. García Mondéjar, L., Lupas, A., Schultz, A., Schultz, J.E. (2012) HAMP Domain-mediated Signal Transduction Probed with a Mycobacterial Adenylyl Cyclase as a Reporter. J. Biol. Chem. 287:1022-1031.
  25. Winkler, K., Schultz, A., Schultz, J.E. (2012) The S-helix determines the signal in a Tsr Receptor/Adenylyl Cyclase Reporter. J. Biol. Chem. 287:15479-15488.
  26. Banjac, A., Kurz, U., Schultz, J.E. (2012) The regulatory tandem domains of human phosphodiesterases 1 and 4 regulate a cyanobacterial adenylyl cyclase. Cell. Sign. 24:1479-1484.
  27. Schultz, J.E., Natarajan, J. (2013) Regulated unfolding: A basic principle of intra-protein signaling in modular proteins. Trends in Biochem. Sci. 38: 538-545.
  28. Natarajan, J., Schultz, A., Kurz, U. Schultz, J.E. (2014) Biochemical characterization of the tandem HAMP domain from Natronomonas pharaonis as an intraprotein signal. FEBS J.281:3218-3227
  29. Schultz, J.E., Kanchan, K., Ziegler, M. (2015) Intraprotein signal transduction by HAMP domains: A balancing act. Int. J. Med. Microbiology 305:243-251
  30. Beltz S, Bassler J, Schultz JE. (2016) Regulation by the quorum sensor from Vibrio indicates a receptor function for the membrane anchors of adenylate cyclases. eLife.13098. doi: 10.7554
  31. Ziegler M, Bassler, J., Beltz S, Lupas AN, Schultz J.E. (2017) Characterization of a novel signal transducer element intrinsic to class IIIa/b adenylate cyclases and guanylate cyclases FEBS J. 284:1204-1217.
  32. Bassler, J., Schultz, J.E., Lupas, A.N. (2018) Adenylate cyclases: Receivers, transducers, and generators of signals. Cellular Signalling 46:135-144.
  33. Galperin, M.Y., Schultz, J.E. (2018) Sensory Transduction in Bacteria. Encyclopedia of Microbiology, 4th Edition: Sensory Transduction in Bacteria, Elsevier ISBN 9780128012383, https://doi.org/10.1016/B978-0-12-801238-3.02458-2. (http://www.sciencedirect.com/science/article/pii/B9780128012383024582).
  34. Wissig, J., Grischin, J., Bassler, J., Schubert, C., Friedrich, T., Bähre, H., Schultz, J.E., Unden, G.  (2019) CyaC, a redox-regulated adenylate cyclase of Sinorhizobium meliloti with a fumarate reductase-like diheme-B membrane anchor. Mol. Microbiol. 112:16-28.
  35.  Finkbeiner, M., Grischin, J., Seth, A., Schultz, J.E. (2019) In search of a function for the membrane anchors of class IIIa adenylate cyclases. Int. J. Med. Microbiol. 309:245-241.
  36.  Seth, A., Finkbeiner, M., Grischin, J., Schultz, J.E. (2020) Gsα stimulation of mammalian adenylate cyclases regulated by their hexahelical membrane anchors. Cellular Signalling 68: https://doi.org/10.1016/j.cellsig.2020.109538