Pharmaceutical Biology

Former Members (Alumni)

Panagiota-Hanna Koutsandrea (PhD)


Daniel Bär (PhD)

Publications:

Bär D, Konetschny B, Kulik A, Xu H, Paccagnella D, Beller P, Ziemert N, Dickschat JS, Gust B. (2022) Origin of the 3-methylglutaryl moiety in caprazamycin biosynthesis. Microb Cell Fact. 21(1):232


Roger Castillo (PhD)

Publications:

Castillo Arteaga RD, Garrido LM, Pedre B, Helmle I, Gross H, Gust B, Padilla G. (2021) Mycothiol Peroxidase Activity as a Part of the Self-Resistance Mechanisms against the Antitumor Antibiotic Cosmomycin D. Microbiol Spectr. 10(3): e0049322


Tomke Bakker (PhD)


Lucia Westrich (Chemical technician)


Tobias Raichle (PhD)


Nils Hauck (PhD)

Publications:

Wiker F, Hauck N, Grond S, Gust B.(2019) Caprazamycins: Biosynthesis and structure activity relationship studies. Int J Med Microbiol. 309(5):319-324.

Bauer JS, Hauck N, Christof L, Mehnaz S, Gust B, Gross H. (2016) The Systematic Investigation of the Quorum Sensing System of the Biocontrol Strain Pseudomonas chlororaphis subsp. aurantiaca PB-St2 Unveils aurI to Be a Biosynthetic Origin for 3-Oxo-Homoserine Lactones. PLoS One. 11(11):e0167002.


Franziska Wiker (PhD)

Publications:

Wiker F, Konnerth M, Helmle I, Kulik A, Kaysser L, Gross H, Gust B. (2019) Identification of Novel α-Pyrones from Conexibacter woesei Serving as Sulfate Shuttles. ACS Chem Biol. 14(9):1972-1980.

Wiker F, Hauck N, Grond S, Gust B.(2019) Caprazamycins: Biosynthesis and structure activity relationship studies. Int J Med Microbiol. 309(5):319-324.


Manuela Rösch (PhD)

Publications:

Basitta P, Westrich L, Rösch M, Kulik A, Gust B, Apel AK. (2017) AGOS: A Plug-and-Play Method for the Assembly of Artificial Gene Operons into Functional Biosynthetic Gene Clusters. ACS Synth Biol. 6(5):817-825.


Kornelia Eitel (PhD)

Publications:

Tang X, Eitel K, Kaysser L, Kulik A, Grond S, Gust B. (2013) A two-step sulfation in antibiotic biosynthesis requires a type III polyketide synthase. Nat Chem Biol. 9(10):610-5.

Gust B, Eitel K, Tang X. (2013) The biosynthesis of caprazamycins and related liponucleoside antibiotics: new insights. Biol Chem. 394(2):251-9.

Kaysser L, Eitel K, Tanino T, Siebenberg S, Matsuda A, Ichikawa S, Gust B. (2010) A new arylsulfate sulfotransferase involved in liponucleoside antibiotic biosynthesis in streptomycetes. J Biol Chem. 285(17):12684-94.
*Kaysser and Eitel contributed equally to this paper


Xiaoyu Tang (PhD)

Present address:

Xiaoyu Tang
Shenzhen Bay Laboratory
Gaoke International Innovation Center,B309
Guangqiao Road, Guangming District
Shenzhen City, Guangdong Province

518107, P.R. China
e-mail: xtang[at]szbl.ac.cn

Publications:

Tang X, Gross M, Xie Y, Kulik A, Gust B. (2013) Identification of Mureidomycin Analogues and Functional Analysis of an N-Acetyltransferase in Napsamycin Biosynthesis. Chembiochem. 14(17):2248-55.

Tang X, Eitel K, Kaysser L, Kulik A, Grond S, Gust B. (2013) A two-step sulfation in antibiotic biosynthesis requires a type III polyketide synthase. Nat Chem Biol. 9(10):610-5.

Gust B, Eitel K, Tang X. (2013) The biosynthesis of caprazamycins and related liponucleoside antibiotics: new insights. Biol Chem. 394(2):251-9.

Kaysser L, Tang X, Wemakor E, Sedding K, Hennig S, Siebenberg S, Gust B. (2011) Identification of a napsamycin biosynthesis gene cluster by genome mining. Chembiochem. 12(3):477-87.
*Kaysser and Tang contributed equally to this paper


Leonard Kaysser (JProf)

Present address:

Prof. Dr. Leonard Kaysser
Institute for Drug Discovery
Department Pharmaceutical Biology
Eilenburger Str. 14
04317 Leipzig
University of Leipzig
Tel: +49 341 97-11941
Fax: +49 341 97-11859
Email: leonard.kaysserspam prevention@uni-leipzig.de

 

Publications:

Tang X, Eitel K, Kaysser L, Kulik A, Grond S, Gust B. (2013) A two-step sulfation in antibiotic biosynthesis requires a type III polyketide synthase. Nat Chem Biol. 9(10):610-5.

Kaysser L, Tang X, Wemakor E, Sedding K, Hennig S, Siebenberg S, Gust B. (2011) Identification of a napsamycin biosynthesis gene cluster by genome mining. Chembiochem. 12(3):477-87.

Siebenberg S, Kaysser L, Wemakor E, Heide L, Gust B, Kammerer B. (2011) Identification and structural elucidation of new caprazamycins from Streptomyces sp. MK730-62F2 by liquid chromatography/electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Rapid Commun Mass Spectrom. 25(4):495-502.

Flinspach K, Westrich L, Kaysser L, Siebenberg S, Gomez-Escribano JP, Bibb M, Gust B, Heide L. (2010) Heterologous expression of the biosynthetic gene clusters of coumermycin A1, clorobiocin and caprazamycins in genetically modified Streptomyces coelicolor strains. Biopolymers. 93(9):823-32.

Kaysser L, Wemakor E, Siebenberg S, Salas JA, Sohng JK, Kammerer B, Gust B. (2010) Formation and attachment of the deoxysugar moiety and assembly of the gene cluster for caprazamycin biosynthesis. Appl Environ Microbiol. 76(12):4008-18.

Kaysser L, Eitel K, Tanino T, Siebenberg S, Matsuda A, Ichikawa S, Gust B. (2010) A new arylsulfate sulfotransferase involved in liponucleoside antibiotic biosynthesis in streptomycetes. J Biol Chem. 285(17):12684-94.

Kaysser L, Siebenberg S, Kammerer B, Gust B. (2010) Analysis of the liposidomycin gene cluster leads to the identification of new caprazamycin derivatives. Chembiochem. 11(2):191-6.

Kaysser L, Lutsch L, Siebenberg S, Wemakor E, Kammerer B, Gust B. (2009) Identification and manipulation of the caprazamycin gene cluster lead to new simplified liponucleoside antibiotics and give insights into the biosynthetic pathway. J Biol Chem. 284(22):14987-96.

Zhao X, Kaysser L. (2009) „Meeting report: the 13th International Biotechnology Symposium and Exhibition in Dalian, China.“ Biotechnology Journal (2009), 4(1):23-7.


Susanne Hennig (Tech. Assistant)

Present address:
Pharmaceutical Chemistry

Pharmaceutical Institute

Auf der Morgenstelle 8

72076 Tübingen, Germany

Publications:

Kaysser L, Tang X, Wemakor E, Sedding K, Hennig S, Siebenberg S, Gust B. (2011) Identification of a napsamycin biosynthesis gene cluster by genome mining. Chembiochem. 12(3):477-87.

Anderle C, Hennig S, Kammerer B, Li SM, Wessjohann L, Gust B, Heide L. (2007) Improved mutasynthetic approaches for the production of modified aminocoumarin antibiotics. Chem Biol. 14(8):955-67.


Liane Lutsch (Dipl. Pharmacist)


Publications:

Kaysser L, Lutsch L, Siebenberg S, Wemakor E, Kammerer B, Gust B. (2009) Identification and manipulation of the caprazamycin gene cluster lead to new simplified liponucleoside antibiotics and give insights into the biosynthetic pathway. J Biol Chem. 284(22):14987-96.


Manuel Wolpert (PhD)

Biologist

Publications:

Wolpert M, Heide L, Kammerer B, Gust B. (2008) Assembly and heterologous expression of the coumermycin A1 gene cluster and production of new derivatives by genetic engineering. Chembiochem. 9(4):603-12.

Wolpert M, Gust B, Kammerer B, Heide L. (2007) Effects of deletions of mbtH-like genes on clorobiocin biosynthesis in Streptomyces coelicolor. Microbiology. 153(Pt 5):1413-23.


Katharina Sedding (Dipl. Pharmacist)


Publications:

Kaysser L, Tang X, Wemakor E, Sedding K, Hennig S, Siebenberg S, Gust B. (2011) Identification of a napsamycin biosynthesis gene cluster by genome mining. Chembiochem. 12(3):477-87.