Subproject A08: Deciphering the plasma membrane-associated responses to mechanical stress
Principal Investigator:
Dr. Thomas Stanislas
Universität Tübingen
ZMBP Developmental Genetics
Auf der Morgenstelle 32
72076 Tübingen
+49 7071 29 73230
thomas.stanislas@zmbp.uni-tuebingen.de
Summary:
How can mechanical stress trigger molecular responses? To tackle this question, we developed a microfluidic device that allows to trap living protoplasts, to induce tightly controlled mechanical stress, coupled with high-resolution microscopy. After assessing different levels of mechanical stress endured by the protoplasts, we will analyse the molecular responses triggered by mechanical stress. These results will give a better understanding of the first steps of mechano-sensing signalling and responses.