Sub-project D03: BIR-mediated cell death - players, mechanisms, specificities
Principle Investigator
Dr. Birgit Kemmerling
Universität Tübingen
ZMBP, Pflanzenbiochemie
Auf der Morgenstelle 32
72076 Tübingen
+49 7071 - 29 76654
Fax +49 7071 - 29 5226
birgit.kemmerling@zmbp.uni-tuebingen.de
Summary
The BRI1-associated kinase BAK1 is a positive regulatory hub in multiple receptor kinase (RK)-mediated signaling pathways and cell death control. BAK1 itself is kept under control by BAK1-interacting RK (BIR) family proteins. We revealed that intracellular immune receptors are involved in BAK1/BIR-mediated cell death. The repertoire and specificity of cell death components will finally be determined. Another BIR3-interacting protein HIR2 will be analyzed for its function in nanocluster formation and how it contributes to plant innate immunity by potentially organizing membrane localized intra- and extracellular immune receptors for linking pattern- and effector-triggered immunity.