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Molecular machines are fascinating devices that drive self-organization in cells.  While the proteins involved in many mechanical processes like transport or cell division have been identified, the mechanical principles that govern their operation are poorly understood.  For example, how much force can molecular machines generate; how are they regulated; and what limits their speed and efficiency?  Currently, our research in cellular nanoscience focuses on developing and applying single-molecule fluorescence and force microscopy techniques - high-resolution optical tweezers and novel probes - to understand how molecular machines, such as kinesin motors, membrane proteins, and DNA repair proteins, work mechanically to fulfil their cellular function.

More information is available on the group homepage of Erik Schäffer.